The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids
| Autor: | I. H. T. Luijendijk, Virgilio P Carnielli, Anneke A. Boerlage, H J Degenhart, Pieter J J Sauer, Darcos J L Wattimena |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Docosahexaenoic Acids Linolenic acid Linoleic acid Biology Gas Chromatography-Mass Spectrometry Linoleic Acid chemistry.chemical_compound Internal medicine medicine Humans Infant Very Low Birth Weight Phospholipids chemistry.chemical_classification Carbon Isotopes Arachidonic Acid alpha-Linolenic acid Infant Newborn alpha-Linolenic Acid Metabolism Low birth weight Endocrinology chemistry Linoleic Acids Docosahexaenoic acid Pediatrics Perinatology and Child Health Arachidonic acid medicine.symptom Infant Premature Polyunsaturated fatty acid |
| Zdroj: | Pediatric research. 40(1) |
| ISSN: | 0031-3998 |
| Popis: | Infants fed formulas devoid of long-chain polyunsaturated fatty acids (LCP) exhibit low plasma LCP concentrations and have poorer retinal and neurologic development in comparison with their human milk-fed counterparts. It is not known whether the low plasma LCP concentrations result from an impaired biosynthetic capacity, a high need or a low dietary intake. With stable isotope technology and high sensitivity tracer detection using gas chromatography-isotope ratio mass spectrometry we measured the conversion of [13C]linoleic acid (C18:2n-6) and [13C]linolenic acid (C18:3n-3) into their longer chain derivatives in five 1-mo-old formula-fed preterm infants (birth weight 1.17 +/- 0.12.kg and gestational age 28.4 +/- 1.3 wk). Carbon-13-labeled linoleic acid and inolenic were mixed with the formula and administered continuously for 48 h. Both tracers were rapidly incorporated in plasma phospholipids, and their metabolic products including arachidonic acid (C20:4n-6) and docosahexaenoic acid (C22:6n-3) became highly enriched. We demonstrate that the preterm infant is capable of synthesizing LCP from their 18-carbon precursors, and our data do not support the hypothesis that a reduced delta 6 desaturation is a main factor leading to low arachidonic acid and docosahexaenoic acid levels. |
| Databáze: | OpenAIRE |
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