Single-dose and Steady-state Pharmacokinetics of a New Oral Suspension of Ciprofloxacin in Children
| Autor: | Heikki Peltola, Ukkonen P, Stass H, Harri Saxen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Drug medicine.medical_specialty Offspring media_common.quotation_subject Administration Oral Physiology Cystic fibrosis Drug Administration Schedule Suspensions Pharmacokinetics Ciprofloxacin Fibrosis Oral administration medicine Humans Child Antibacterial agent media_common business.industry Infant medicine.disease Surgery Child Preschool Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | Pediatrics. 101:658-662 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.101.4.658 |
| Popis: | Objective. Quinolones are used ever increasingly in pediatrics, although officially they are still contraindicated. Lack of evidence of arthropathic effects in human offspring favors their use, but little is known about the pharmacokinetics of oral or parenteral ciprofloxacin in children, especially those without cystic fibrosis. Design. We studied 16 non-cystic fibrosis patients ranging in age from 0.3 to 7.1 years to whom the new suspension formulation of ciprofloxacin (10 mg/kg body weight) was given orally three times daily. Single-dose and steady-state pharmacokinetic parameters were elucidated. Results. Ciprofloxacin was rapidly absorbed. The maximum plasma concentrations, with the means varying from 1.7 to 3.6 mg/L, were reached within 1 hour, almost regardless of whether single-dose administration or steady state. The mean oral clearance was lower in children Conclusion. A dose of the suspension form of ciprofloxacin of 10 mg/kg body weight given orally three times daily seems appropriate in children, provided the drug is clearly indicated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|