Prognostic value of the dynamics of M-type phospholipase A2 receptor antibody titers in patients with idiopathic membranous nephropathy treated with two different immunosuppression regimens
| Autor: | Alfonso Segarra Medrano, Elías Jatem Escalante, Elena Ostos Roldán, Natalia Ramos Terrades, Karla Viviana Arredondo Agudelo, Irene Agraz Pamplona, Naiara Valtierra Carmeno, Maria Teresa Salcedo Allende, Juliana Jaramillo Vasquez, Clara Carnicer Cáceres |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Health Toxicology and Mutagenesis medicine.medical_treatment Clinical Biochemistry Glomerulonephritis Membranous Biochemistry Membranous nephropathy Humans Medicine In patient Autoantibodies biology business.industry Receptors Phospholipase A2 Antibody titer Immunosuppression Middle Aged Prognosis medicine.disease Idiopathic Membranous Nephropathy Treatment Outcome Immunology biology.protein Female Rituximab Antibody business Biomarkers Immunosuppressive Agents Phospholipase A2 receptor medicine.drug |
| Zdroj: | Biomarkers. 20:77-83 |
| ISSN: | 1366-5804 1354-750X |
| Popis: | Context: The dynamics of anti-phospholipase A2 antibody titers during treatment could predict clinical responses in patients with membranous nephropathy.Objectives: We analyzed the predictive value of the dynamics of these antibodies on clinical responses.Materials and methods: The serum antibody levels were measured before and during treatment in 79 patients with anti-phospholipase A2 receptor antibody membranous nephropathy treated with two different immunosuppression regimensResults: In both groups of patients, the relative reduction in antibody titers at 3 and 6 months preceded and predicted the clinical responses.Conclusions: Antibody titer dynamics was useful for predicting clinical responses. |
| Databáze: | OpenAIRE |
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