Association between Type 2 diabetes mellitus and TCF7L2 and FTO gene variants among upper Egyptian population
| Autor: | M. Hossam Maghraby, Refat Fathy, Sara Atta, Mohammed Hassan Mostafa, Ayat A. Sayed, Taghreed A. Ismael, Heba M. Abdelraouf, Ghada Abdelrahman |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Egyptian Journal of Hospital Medicine; Vol. 86 No. 1 (2022); 924-933 |
| ISSN: | 1687-2002 2090-7125 |
| Popis: | Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder caused by a complex interaction of genetic and environmental variables. T2DM is associated with transcription factor 7-like 2 (TCF7L2) and fat mass and obesity-associated (FTO) genetic polymorphism.Objectives: The goal of this study was to examine the common genetic risk factors of T2DM and related metabolic traits in Upper Egyptian population, in attempt to understand the genetic structure of T2DM in the Egyptian community.Methods and Materials: This case control study included 250 participants, 124 T2DM patients and 126 non-diabetics. Using mutagenically separated polymerase chain reaction (MS-PCR), genotyping of single nucleotide polymorphisms (SNP) rs7903146 of TCF7L2 and rs17817449 of FTO genes was carried out.Results: T allele of TCF7L2 variant rs7903146 confers a risk for T2DM (allelic OR=1.97, 95% CI: (1.34 to 2.88) p = |
| Databáze: | OpenAIRE |
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