Neutrophil DREAM come true: The not-so-impossible quest for mechanisms of neutrophil function and heterogeneity

Autor:	John C. Gomez, Claire M. Doerschuk
Rok vydání:	2021
Předmět:	Neutrophils Immunology Endothelial Cells Correction Immunology and Allergy
Zdroj:	The Journal of Experimental Medicine
ISSN:	1540-9538 0022-1007
DOI:	10.1084/jem.20212141
Popis:	Neutrophil functions and responses are heterogeneous, and the nature and categorization of this heterogeneity is achieving considerable interest. Work by Li et al. in this issue of JEM (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211083) identifies how a transcriptional repressor, DREAM, regulates adhesion of neutrophils to endothelial cells and their transmigration into tissue. This study offers a mechanism for heterogeneity in this critical response of neutrophils to inflammatory stimuli.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c8040742e8be2b39cbd67959d8d421 https://doi.org/10.1084/jem.20212141 Zobrazit plný text záznamu