Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain): Implications for Prevention of Cervical Cancer

Autor: Carmen Alcalde, Aureli Torné, Valeria Stuardo, Antoni Tarrats, Josefa Solé, Jordi Casabona, J.M. Godínez, Belen Lloveras, Cristina Vanrell, Josep María Miro, Yolanda Canet, Pere Domingo, José Manuel Marqueta, Cristina Agustí, Eulalia Fernández-Montoli, Guillem Sirera, Alexandra Montoliu, Elena Ferrer, Jadiyettu Mohamed, Silvia de Sanjosé, Montserrat Lonca, Isabel Cuenca, Dolores Martín
Přispěvatelé: Universitat de Barcelona
Předmět:
Health Screening
Epidemiology
Dones
HIV Infections
Cervix cancer
Pregnancy
Medicine
Papillomaviridae
Early Detection of Cancer
Colposcopy
Cervical cancer
education.field_of_study
Multidisciplinary
Cervical screening
biology
medicine.diagnostic_test
Obstetrics
HPV infection
Middle Aged
HIV epidemiology
Infectious diseases
Female
Public Health
Cancer Epidemiology
Research Article
Papanicolaou Test
Adult
medicine.medical_specialty
Human Papillomavirus Infection
Catalonia
Infectious Disease Control
Genotype
Càncer de coll uterí
Papillomaviruses
Science
Population
Sexually Transmitted Diseases
Retrovirology and HIV immunopathogenesis
Viral diseases
Cervical intraepithelial neoplasia
Infectious Disease Epidemiology
Medicina preventiva
VIH (Virus)
Humans
Women
education
Papil·lomavirus
Gynecology
Vaginal Smears
Preventive medicine
business.industry
HIV (Viruses)
Papillomavirus Infections
HIV
Catalunya
Odds ratio
biology.organism_classification
medicine.disease
Uterine Cervical Dysplasia
Tumor Virus Infections
Spain
HIV-1
Women's Health
Preventive Medicine
business
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
PLoS ONE, Vol 7, Iss 10, p e47755 (2012)
PLoS ONE
Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 1932-6203
Popis: Background: High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women. Methods: We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological checkup, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis. Results: Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age < 30 years (odds ratio[OR], 2.5; 95% confidence interval[CI], 1.1-5.6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count < 200cells/mm(3) versus > 500cells/mm(3) (OR, 8.4; 95% CI, 3.7-19.2), HIV-1 viral load > 10,000copies/mL versus < 400copies/mL (OR, 2.1; 95% CI, 1.0-4.4), and use of oral contraceptives (OR, 2.0; 95% CI, 1.0-3.9). Sixty percent of HIV-1-infected women had had one Pap smear within the last 2 years. Conclusions: The high prevalence of HPV infection and cervical lesions in the HIV-1-infected population in Catalonia, as well as the low coverage and frequency of screening in this group, means that better preventive efforts are necessary and should include vaccination against HPV, better accessibility to screening programs, training of health care professionals, and specific health education for HIV-1-infected women.
Databáze: OpenAIRE
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