Protective effect of black relative to white race against non-alcoholic fatty liver disease in patients with severe obesity, independent of type 2 diabetes
| Autor: | Jad Khoraki, Guilherme S. Mazzini, Luke G. Wolfe, Jonathan H. DeAntonio, Matthew G. Browning, Guilherme M. Campos, M S Siddiqui, Martin J. Mangino |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis endocrine system diseases Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Type 2 diabetes Disease digestive system Gastroenterology White People Cohort Studies 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Diabetes mellitus Internal medicine Humans Medicine Nutrition and Dietetics business.industry Fatty liver nutritional and metabolic diseases Middle Aged medicine.disease Obesity digestive system diseases Obesity Morbid Black or African American Diabetes Mellitus Type 2 Female 030211 gastroenterology & hepatology Steatohepatitis business Body mass index |
| Zdroj: | International Journal of Obesity. 42:926-929 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/ijo.2017.309 |
| Popis: | Severe obesity (body mass index ⩾35 kg m-2) and type 2 diabetes (T2D) are potent and additive risk factors for non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH). Scant available evidence indicates that black relative to white patients with severe obesity are less susceptible to NAFLD, but it is unclear if T2D abolishes this apparent racial disparity. Therefore, we compared biopsy-proven NAFLD and its progression between black (n=71) and white (n=155) patients with severe obesity stratified by presence or absence of T2D. Although prevalence of T2D was similar between races (37%, P>0.9), whites were significantly more likely than blacks to have NAFLD, NASH and advanced fibrosis (defined as bridging fibrosis and/or cirrhosis). Importantly, T2D was associated with increased odds of NAFLD, NASH and advanced fibrosis (defined as bridging fibrosis or cirrhosis) in whites only (P |
| Databáze: | OpenAIRE |
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