Probabilistic neural network approach for the detection of SAHS from overnight pulse oximetry
| Autor: | Nicole Gross, Daniel Sánchez Morillo |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Multivariate statistics Polysomnography Speech recognition Biomedical Engineering Feature selection Cross-validation Probabilistic neural network medicine Humans Oximetry Aged Aged 80 and over Analysis of Variance Sleep Apnea Obstructive medicine.diagnostic_test business.industry Univariate Reproducibility of Results Sleep apnea Pattern recognition Middle Aged medicine.disease nervous system diseases Computer Science Applications Pulse oximetry ROC Curve Female Neural Networks Computer Artificial intelligence business |
| Zdroj: | Medical & Biological Engineering & Computing. 51:305-315 |
| ISSN: | 1741-0444 0140-0118 |
| DOI: | 10.1007/s11517-012-0995-4 |
| Popis: | Diagnosis of sleep apnea hypopnoea syndrome (SAHS) depends on the apnea-hypopnea index determined by the standard in-laboratory overnight polysomnography (PSG). PSG is a costly, labor intensive and, at times, inaccessible approach. Because of the high demand, the need for timely diagnosis and the associated costs, novel methods for SAHS detection are required. In this study, a novel multivariate system is proposed for SAHS detection from the analysis of overnight blood oxygen saturation (SpO2). 115 subjects with SAHS suspicion were studied. A starting set of 17 time domain, stochastic, frequency-domain and nonlinear features were initially computed from SpO2 recordings. Sequential forward feature selection and a probabilistic neural network with leave-one-out cross-validation were applied. Oxygen desaturations below a 4 % threshold within 30 s (ODI430), restorations of 4 % within 10 s (RES4), median value (Sat50), SD1 Poincaré descriptor and the relative power in the 0.013-0.067 Hz frequency band (PSD15/75) formed the optimum features subset. 92.4 % sensitivity and 95.9 % specificity were achieved. Results significantly outperformed the univariate and multivariate approaches reported in literature. The outcome is a simple cost-effective tool that could be used as an alternative or supplementary method in a domiciliary approach to early diagnosis of SAHS. |
| Databáze: | OpenAIRE |
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