Peritonitis outcomes in patients with HIV and end-stage renal failure on peritoneal dialysis: a prospective cohort study

Autor: Alain Assounga, Kwazi C. Z. Ndlovu, Wilbert Sibanda
Rok vydání: 2017
Předmět:
Adult
Male
Nephrology
medicine.medical_specialty
medicine.medical_treatment
030232 urology & nephrology
Peritonitis
HIV Infections
Technique failure
Continuous ambulatory peritoneal dialysis (CAPD)
030204 cardiovascular system & hematology
Peritoneal dialysis
Cohort Studies
South Africa
03 medical and health sciences
0302 clinical medicine
Peritoneal Dialysis
Continuous Ambulatory

Risk Factors
Antiretroviral Therapy
Highly Active

Internal medicine
medicine
Humans
Prospective Studies
Renal replacement therapy
Prospective cohort study
Proportional Hazards Models
2. Zero hunger
business.industry
Continuous ambulatory peritoneal dialysis
HIV
Middle Aged
medicine.disease
Catheter failure
End-stage renal disease (ESRD)
CD4 Lymphocyte Count
3. Good health
Case-Control Studies
Catheter-Related Infections
Cohort
Kidney Failure
Chronic

Equipment Failure
Female
Infection
business
Research Article
Cohort study
Zdroj: BMC Nephrology
ISSN: 1471-2369
DOI: 10.1186/s12882-017-0466-0
Popis: Background Few studies have investigated the management of human immunodeficiency virus (HIV)-associated end-stage renal failure particularly in low-resource settings with limited access to renal replacement therapy. We aimed to evaluate the effects of HIV infection on continuous ambulatory peritoneal dialysis (CAPD)-associated peritonitis outcomes and technique failure in highly active antiretroviral therapy (HAART)-treated HIV-positive CAPD populations. Methods We conducted a single-center prospective cohort study of consecutive incident CAPD patients recruited from two hospitals in Durban, South Africa from September 2012-February 2015. Seventy HIV-negative and 70 HIV-positive end-stage renal failure patients were followed monthly for 18 months at a central renal clinic. Primary outcomes of peritonitis and catheter failure were assessed for the first 18 months of CAPD therapy. We assessed risk factors for peritonitis and catheter failure using Cox regression survival analysis. Results The HIV-positive cohort had a significantly increased rate of peritonitis compared to the HIV-negative cohort (1.86 vs. 0.76 episodes/person-years, respectively; hazard ratio [HR], 2.41; 95% confidence interval [CI], 1.69–3.45, P
Databáze: OpenAIRE