Peritonitis outcomes in patients with HIV and end-stage renal failure on peritoneal dialysis: a prospective cohort study
Autor: | Alain Assounga, Kwazi C. Z. Ndlovu, Wilbert Sibanda |
---|---|
Rok vydání: | 2017 |
Předmět: |
Adult
Male Nephrology medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology Peritonitis HIV Infections Technique failure Continuous ambulatory peritoneal dialysis (CAPD) 030204 cardiovascular system & hematology Peritoneal dialysis Cohort Studies South Africa 03 medical and health sciences 0302 clinical medicine Peritoneal Dialysis Continuous Ambulatory Risk Factors Antiretroviral Therapy Highly Active Internal medicine medicine Humans Prospective Studies Renal replacement therapy Prospective cohort study Proportional Hazards Models 2. Zero hunger business.industry Continuous ambulatory peritoneal dialysis HIV Middle Aged medicine.disease Catheter failure End-stage renal disease (ESRD) CD4 Lymphocyte Count 3. Good health Case-Control Studies Catheter-Related Infections Cohort Kidney Failure Chronic Equipment Failure Female Infection business Research Article Cohort study |
Zdroj: | BMC Nephrology |
ISSN: | 1471-2369 |
DOI: | 10.1186/s12882-017-0466-0 |
Popis: | Background Few studies have investigated the management of human immunodeficiency virus (HIV)-associated end-stage renal failure particularly in low-resource settings with limited access to renal replacement therapy. We aimed to evaluate the effects of HIV infection on continuous ambulatory peritoneal dialysis (CAPD)-associated peritonitis outcomes and technique failure in highly active antiretroviral therapy (HAART)-treated HIV-positive CAPD populations. Methods We conducted a single-center prospective cohort study of consecutive incident CAPD patients recruited from two hospitals in Durban, South Africa from September 2012-February 2015. Seventy HIV-negative and 70 HIV-positive end-stage renal failure patients were followed monthly for 18 months at a central renal clinic. Primary outcomes of peritonitis and catheter failure were assessed for the first 18 months of CAPD therapy. We assessed risk factors for peritonitis and catheter failure using Cox regression survival analysis. Results The HIV-positive cohort had a significantly increased rate of peritonitis compared to the HIV-negative cohort (1.86 vs. 0.76 episodes/person-years, respectively; hazard ratio [HR], 2.41; 95% confidence interval [CI], 1.69–3.45, P |
Databáze: | OpenAIRE |
Externí odkaz: |