Coronary tortuosity is associated with an elevated high-sensitivity C-reactive protein concentration and increased risk of ischemic stroke in hypertensive patients
| Autor: | Chengxing Shen, Jiayi Tong, Genshan Ma, Naifeng Liu, Yang Li, Abdul Qadir Nawabi, Yi Feng |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Medicine (General) medicine.medical_specialty hypertension Lacunar infarction 030204 cardiovascular system & hematology Biochemistry Tortuosity Clinical Reports Brain Ischemia Coronary artery disease 03 medical and health sciences R5-920 0302 clinical medicine lacunar infarction Risk Factors Internal medicine Humans Medicine Coronary tortuosity biology business.industry Biochemistry (medical) C-reactive protein Cell Biology General Medicine Middle Aged medicine.disease Coronary Vessels Stroke C-Reactive Protein Increased risk Ischemic stroke Cardiology biology.protein Female high-sensitivity C-reactive protein cerebrovascular accident business coronary artery disease 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of International Medical Research, Vol 46 (2018) The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Objective The clinical implication of coronary tortuosity is unclear. The present study was conducted to determine the relationships between coronary tortuosity and the high-sensitivity C-reactive protein (hs-CRP) concentration and between coronary tortuosity and cerebrovascular accident in hypertensive patients without coronary artery disease. Methods In total, 236 patients with normal coronary angiography findings were categorized into 3 different groups: control participants (n = 58), who had neither hypertension nor coronary tortuosity; patients with hypertension but no coronary tortuosity (H-NCT group, n = 93); and patients with both hypertension and coronary tortuosity (H-CT group, n = 85). The hs-CRP concentration was measured in every patient, and 168 hypertensive patients were followed up for at least 2 years to check for the development of cerebrovascular accident. Results The hs-CRP concentration was significantly higher in the H-CT group than in the control and H-NCT groups (4.33 ± 3.15 vs. 1.52 ± 1.31 and 2.31 ± 2.09 mg/L, respectively). The incidence of lacunar infarction was higher in the H-CT than H-NCT group during the follow-up. Conclusions Hypertensive patients with coronary tortuosity have a higher serum hs-CRP level concentration and have a higher incidence of lacunar infarction than hypertensive patients without coronary tortuosity. |
| Databáze: | OpenAIRE |
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