Gastric Cancer: Establishing Predictors of Biologic Behavior with Use of Population-Based Data

Autor: Carol E. Cass, Bryan J. Dicken, S. M. Hamilton, C. de Gara, S. Andrews, G. S. Jhangri, L. D. Saunders
Rok vydání: 2004
Předmět:
Zdroj: Annals of Surgical Oncology. 11:629-635
ISSN: 1534-4681
1068-9265
DOI: 10.1245/aso.2004.09.002
Popis: Tumor thickness and nodal status are important predictors of survival following curative resection for gastric cancer. Lymphovascular invasion (LVI) is a potential predictor of biological behavior. The relationship between LVI and tumor thickness (T status) has not been established in population-based studies.Clinicopathological and survival data of 577 patients at nine centers, from between 1991 and 1997, was collected from patient records and a Provincial Cancer Registry. The primary endpoint of the study was death. A secondary analysis of a node-negative subgroup examined the significance of LVI with respect to T status.The population disease-specific survival was 28%. In a multivariate analysis, T, N, M, esophageal margin, tumor morphology, and residual tumor category were independent predictors of survival. LVI was documented in 58% of resected tumors. LVI correlated with advancing T and N status but was not significant in a multivariate population model. Subgroup analysis of node-negative gastric cancer found T status and LVI to be independent predictors of survival. LVI was associated with a 5-year survival of 8%, versus 43% among patients in whom it was absent (P.001).T status and N status were the most important independent predictors of survival in a population-based study of gastric cancer. LVI correlated with advancing N and T status. Multivariate analysis of node-negative patients showed LVI and T status are independent predictors of survival.
Databáze: OpenAIRE
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