Advancements in catheter-directed ultrasound-accelerated thrombolysis

Autor: Clark J. Zeebregts, Denise E. Doomernik, Jean-Paul P. M. de Vries, Michel M.P.J. Reijnen, A. Marjolein Schrijver
Přispěvatelé: Man, Biomaterials and Microbes (MBM), Vascular Ageing Programme (VAP)
Rok vydání: 2011
Předmět:
medicine.medical_specialty
ACUTE MYOCARDIAL-INFARCTION
pulmonary embolism
Catheters
medicine.medical_treatment
HUMAN CLOT MODEL
Ultrasonic Therapy
DEEP VENOUS THROMBOSIS
LOW-FREQUENCY ULTRASOUND
Revascularization
Catheterization
Fibrinolytic Agents
medicine
Animals
Humans
Radiology
Nuclear Medicine and imaging
INITIAL CLINICAL-EXPERIENCE
Thrombolytic Therapy
Myocardial infarction
Embolization
ACUTE ISCHEMIC-STROKE
Stroke
TISSUE-PLASMINOGEN ACTIVATOR
catheter-directed thrombolysis
Functional Neurogenomics Implementation Science [DCN 2]
business.industry
ultrasound
Standard treatment
IN-VITRO THROMBOLYSIS
Thrombolysis
medicine.disease
stroke
Pulmonary embolism
MASSIVE PULMONARY-EMBOLISM
Venous thrombosis
Treatment Outcome
Cardiovascular Diseases
Surgery
Radiology
Cardiology and Cardiovascular Medicine
business
arterial occlusion
PERCUTANEOUS MECHANICAL THROMBECTOMY
Zdroj: Journal of Endovascular Therapy, 18(3), 418-434. SAGE Publications Inc.
Journal of Endovascular Therapy, 18, 3, pp. 418-34
Journal of Endovascular Therapy, 18, 418-34
ISSN: 1545-1550
1526-6028
Popis: Item does not contain fulltext PURPOSE: To review all available literature on catheter-directed ultrasound-accelerated thrombolysis for peripheral artery occlusions, stroke, deep venous thrombosis, and pulmonary embolism. METHODS: A systematic literature search was performed, using MEDLINE, EMBASE and Cochrane databases. A total of 77 reports focusing on catheter-delivered ultrasound-accelerated thrombolysis were identified. RESULTS: Experimental studies show that high intensity ultrasound may induce thrombolysis, with and without the addition of plasminogen activators, mainly by acoustic cavitation and mechanical disruption, while low intensity, high frequency ultrasound waves may actually enhance plasmin-mediated thrombolysis. In a total of 340 clinical cases of various thromboembolic conditions, catheter-directed ultrasound-accelerated thrombolysis was related to rapid revascularization and a reduction in treatment time, drug dosage, hospitalization time, and possibly major bleeding complications compared to standard thrombolysis. Reported complication rates, including bleeding and embolization, were low. CONCLUSION: Ultrasound enhanced thrombolysis seems to be a promising concept in the treatment of various thromboembolic conditions. The technique has shown to be safe and efficacious in vitro, in vivo, and in clinical studies. Randomized controlled trials are warranted and should be awaited before considering catheter-directed ultrasound-accelerated thrombolysis as a new standard treatment. 01 juni 2011
Databáze: OpenAIRE
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