Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)
| Autor: | Hong Ru Yang, Xing Xia Wang, Dai Jie Wang, Jian Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
PD-L1
0301 basic medicine Cancer Research Synbiotics medicine.medical_treatment Context (language use) Review Gut flora digestive system antibiotics traditional Chinese medicine 03 medical and health sciences fluids and secretions 0302 clinical medicine Cancer immunotherapy PD-1 medicine FMT biology business.industry Cancer Immunotherapy biology.organism_classification medicine.disease 030104 developmental biology Oncology CTLA-4 030220 oncology & carcinogenesis Immunology biology.protein business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2020.12205 |
| Popis: | Studies are increasingly investigating the association between the gut microbiota and the outcomes of immunotherapy in patients with cancer. Notably, certain studies have demonstrated that the gut microbiota serves a key role in regulating a patient's response to immunotherapy. In the present review, the potential associations between the gut microbiota, and cancer, host immunity and cancer immunotherapy are reviewed. Furthermore, the effects of fecal microbiota transplantation, antibiotics, probiotics, prebiotics, synbiotics, components of traditional Chinese medicine and various lifestyle factors on the gut microbiota and cancer immunotherapy outcomes are discussed. Certain dominant bacterial groups in the context of cancer immunotherapy and certain effective methods for optimizing immunotherapy by regulating the gut microbiota have been identified. Further investigation may enable the rapid conversion of these discoveries into practical products and clinically applicable methods. |
| Databáze: | OpenAIRE |
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