Importance of Anatomical Efficacy for Disease Control in Neovascular AMD: An Expert Opinion

Autor:	Konstantinos Balaskas, Philip Severn, Winfried M Amoaku, Louise Downey, Hemal Mehta, Markus Groppe, Bushra Mushtaq, Tomas Cudrnak, Sajjad Mahmood, Yit C. Yang, Quresh Mohamed, Athanasios Vardarinos
Rok vydání:	2021
Předmět:	Protocol (science) medicine.medical_specialty genetic structures business.industry Best practice Review Guideline Macular degeneration medicine.disease Disease control Disease control fluid eye diseases Ophthalmology Regimen OCT Multidisciplinary approach medicine Treatment strategy sense organs Intensive care medicine business Stability Anatomical efficacy
Zdroj:	Ophthalmology and Therapy
ISSN:	2193-6528 2193-8245
Popis:	Background Neovascular age-related macular degeneration (nAMD) presents a significant treatment burden for patients, carers and medical retina services. However, significant debate remains regarding how best to manage nAMD when assessing disease activity by optical coherence tomography (OCT), and particularly the significance of different types of fluid and how the understanding of anatomical efficacy can influence treatment strategies. This article provides opinion on the practical implications of anatomical efficacy and significance of fluid in the management of nAMD and proposes recommendations for healthcare professionals (HCPs) to improve understanding and promote best practice to achieve disease control. Methods An evidence-based review was performed and an expert panel debate from the Retina Outcomes Group (ROG), a forum of retinal specialists, provided insights and recommendations on the definition, role and practical implications of anatomical efficacy and the significance of fluid at the macula in the management of nAMD. Results The ROG has developed recommendations for achieving disease control through a zero-tolerance approach to the presence of fluid in nAMD as patients who avoid fluctuations in fluid at the macula have better visual outcomes. Recommendations cover five key areas: service protocol, training, regimen, multidisciplinary teams and engagement. This approach facilitates more standardised protocol-based treatment strategies. Conclusions Targeting a fluid-free macula and aiming for disease control are essential to improve outcomes. As new therapies and technologies become available, drying the macula and maintaining disease control will become even more achievable. The outlined recommendations aim to promote best practice among HCPs and medical retina services to improve patient outcomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bae7aa723aaf4a195d30959c5ca61c https://doi.org/10.1007/s40123-021-00342-5 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.