Altered gamma and theta oscillations during multistable perception in schizophrenia
| Autor: | Christina Schmiedt-Fehr, Annika Susann Wienke, Linda Rürup, Ayşegul Özerdem, Andreas Brand, Canan Basar-Eroglu, Birgit Mathes |
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| Rok vydání: | 2019 |
| Předmět: |
Male
genetic structures media_common.quotation_subject Sensory system Multistable perception Stimulus (physiology) Electroencephalography 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Physiology (medical) Perception Biological neural network medicine Reaction Time Humans 0501 psychology and cognitive sciences Theta Rhythm media_common medicine.diagnostic_test General Neuroscience 05 social sciences Brain Cognition Theta oscillations Neuropsychology and Physiological Psychology Time Perception Schizophrenia Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | International journal of psychophysiology : official journal of the International Organization of Psychophysiology. 155 |
| ISSN: | 1872-7697 |
| Popis: | Objective Coherent object perception in patients with schizophrenia is known to be impaired. Oscillatory brain dynamics constitute a fundamental mechanism for the coordinated communication of neural circuits. Such dynamics have been proposed to reflect impaired spatio-temporal integration of sensory and cognitive processes during object perception in schizophrenia. Method EEG recordings of patients with schizophrenia (n = 23) and control participants (n = 23) were examined. Presented were either an ambiguous (multistable) stimulus, endogenously inducing switching between two perceptual alternatives, or a slightly modified unambiguous control stimulus, during which perceptual reversals were triggered by a minor change in the stimulus configuration. Event-related amplitude modulation induced by perceptual reversals was analyzed for theta (3–8 Hz) and gamma band oscillations (28–48 Hz). Results Patients displayed increased reaction times and more errors when indicating unambiguous reversals. The patients´ amplitude enhancement of theta oscillations was diminished in both task conditions. During the control task were gamma amplitudes larger in patients than in healthy participants. Conclusion The results indicate that impairments in generating coherent percepts are reflected in alterations of multiple frequency bands and time windows. Changes in gamma band oscillations may reflect the patients' impairments in perceptuo-cognitive integration processes. Diminished theta amplitude modulation in patients further emphasize diminished top-down cognitive control during perceptual reversals. Significance This study provides insight into how theta and gamma oscillations underlie changes in object perception, and thereby possibly the generation of core symptoms, in schizophrenia. This paper is dedicated to Prof. Dr. Erol Basar, a pioneer in research on oscillatory braindynamics. He was tireless in his effort to understand brain functions and integratedphilosophy, physics, biology and psychology in his research. His vision on how informationis coded in brain networks inspired many researchers in the last 40 years. With him, we not only lose an exceptional researcher, but also a supportive academic teacher and mentor with a persistent, prolific enthusiasm for international and collaborative projects. |
| Databáze: | OpenAIRE |
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