Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats
| Autor: | Subhash L. Bodhankar, Amit D. Kandhare, Pinaki Ghosh |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Angiogenesis medicine.medical_treatment Interleukin-1beta Neovascularization Physiologic Apoptosis Toxicology Collagen Type I Rats Sprague-Dawley chemistry.chemical_compound Random Allocation Transforming Growth Factor beta Diabetes mellitus Internal medicine medicine Tetrachlorodecaoxide Animals Insulin RNA Messenger Insulin-Like Growth Factor I Naringin Glycated Hemoglobin Wound Healing business.industry Histocytochemistry Interleukin-6 Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha General Medicine Streptozotocin medicine.disease Diabetic Foot Endocrinology Diabetic foot ulcer chemistry Gene Expression Regulation Flavanones Angiotensin I business Wound healing medicine.drug |
| Zdroj: | Chemico-biological interactions. 219 |
| ISSN: | 1872-7786 |
| Popis: | Chronic, unhealed diabetic foot ulcer (DFU) is one of the most severe complications of diabetes mellitus (DM). Naringin, a flavanone glycoside antioxidant, was reported to have antidiabetic and anti-apoptotic properties. In the present study DM was induced experimentally by streptozotocin (STZ, 55 mg/kg, i.p.). In surgically introduced wounds on the dorsal surface of the hind paw of rats, the healing potential of naringin was investigated. Rats were treated with naringin (20, 40 and 80 mg/kg, p.o.), insulin (10 IU/kg, s.c.) and tetrachlorodecaoxide (TCDO) (1 drop, twice a day, topically) for 16 days. The wound area was measured every second day, and on day 17 various biochemical parameters were determined in serum, wound tissue, and histopathological examination of the wound was performed. Naringin (40 and 80 mg/kg) significantly (P |
| Databáze: | OpenAIRE |
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