Serum Galectin-3 level and recurrence of atrial fibrillation post-ablation – Systematic review and meta-analysis
| Autor: | Sunu Budhi Raharjo, Veresa Chintya, Raymond Pranata, Emir Yonas, Alexander Edo Tondas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty medicine.medical_treatment Catheter ablation 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Fibrosis Physiology (medical) Internal medicine medicine Galectin-3 030212 general & internal medicine business.industry Atrial fibrillation Atrial fibrillation recurrence Biomarker medicine.disease Ablation Increased risk lcsh:RC666-701 Meta-analysis Biomarker (medicine) Original Article Cardiology and Cardiovascular Medicine business Arrhythmia |
| Zdroj: | Indian Pacing and Electrophysiology Journal Indian Pacing and Electrophysiology Journal, Vol 20, Iss 2, Pp 64-69 (2020) |
| ISSN: | 0972-6292 |
| DOI: | 10.1016/j.ipej.2020.02.002 |
| Popis: | Background: Serum galectin-3, a circulating biomarker of fibrosis, has been associated with atrial remodelling. Recent studies investigating serum galectin-3 and AF recurrence post-ablation have shown mixed results. We aimed to analyze the latest evidence on the association between serum galectin-3 and AF recurrence after catheter ablation. Methods: We performed a comprehensive search on topics that assesses serum galectin-3 and AF recurrence post-ablation up until August 2019. Results: There were 597 patients from seven studies. The mean difference of serum galectin-3 was similar in both AF recurrence and non AF recurrence group (mean difference 0.78 ng/mL [-0.56, 2.13]; p = 0.25; I2: 69%. Upon removal of a study in sensitivity analysis, the serum galectin-3 became higher in AF recurrence group (mean difference 1.41 ng/mL [0.47, 2.34], p = 0.003; I2: 17%). Serum galectin-3 was associated with a higher risk for AF recurrence (HR 1.25 [1.01, 1.55]; p = 0.04; I2: 76%). Upon removal of a study in sensitivity analysis, HR became 1.45 [1.07, 1.96], p = 0.02; I2: 47%. Meta-analysis of adjusted HR demonstrated that high serum galectin-3 independently predicts AF recurrence (HR 1.15 [1.02, 1.29], p |
| Databáze: | OpenAIRE |
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