Serologic response to Mannheimia haemolytica in calves concurrently inoculated with inactivated or modified-live preparations of M haemolytica and viral combination vaccines containing modified-live bovine herpesvirus type 1
| Autor: | Victor S. Cortese, Jon T. Seeger, Breck D. Hunsaker, Gordon W. Brumbaugh, Gerald S. Stokka, Daniel J Weigel, Gregory P. Lardy |
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| Rok vydání: | 2011 |
| Předmět: |
Male
viruses Bacterial Toxins Cattle Diseases Exotoxins MANNHEIMIA HAEMOLYTICA Antibodies Viral Serology Microbiology Random Allocation Animals Vaccines Combined Mannheimia haemolytica Respiratory Tract Infections Herpesvirus 1 Bovine General Veterinary biology Inoculation Viral Vaccine Age Factors Antibody titer Viral Vaccines General Medicine Antibodies Bacterial Virology Titer Vaccines Inactivated Bovine herpesvirus Bacterial Vaccines biology.protein Cattle Female Immunization Antibody |
| Zdroj: | American Journal of Veterinary Research. 72:1541-1549 |
| ISSN: | 0002-9645 |
| DOI: | 10.2460/ajvr.72.11.1541 |
| Popis: | Objective—To assess the serologic response of calves to inactivated and modified-live (ML) Mannheimia haemolytica (MH) preparations given alone and concurrently with combination viral vaccines containing ML bovine herpesvirus type 1 (BHV-1). Animals—642 calves seronegative for BHV-1. Procedures—In experiment 1, 192 calves received 1 of 3 MH preparations alone or concurrently received 1 of 3 MH preparations and 1 of 4 combination viral vaccines. In experiment 2, 450 calves received 1 of 4 MH preparations alone or concurrently received 1 of 4 MH preparations and 1 of 5 combination viral vaccines. Pretreatment and posttreatment blood samples were processed to obtain serum, which was analyzed to detect concentrations of antibodies against MH leukotoxin and BHV-1. Results—In experiment 1, antibody titers against MH leukotoxin in calves receiving MH and ML virus vaccine appeared decreased, albeit nonsignificantly, compared with titers for calves receiving MH preparations alone. In experiment 2, all groups (except for 1) concurrently receiving an MH preparation and viral vaccine had a significant decrease in antibodies against MH leukotoxin. In both experiments, there was a significant decrease in the number of calves responding to MH leukotoxin when ML viral vaccine was coadministered. Conclusions and Clinical Relevance—Coadministration of ML BHV-1 and MH preparations interfered with the serologic response to MH leukotoxin in calves seronegative for BHV-1. Serologic response to MH leukotoxin may be substantially improved in seronegative calves when MH vaccination is delayed until after calves have received a dose of ML BHV-1 vaccine. |
| Databáze: | OpenAIRE |
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