Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) procedure: A novel cell therapy‐based pilot study
| Autor: | Samuel J. K. Abraham, Surya Prakash Vaddi, Vijaya Bhaskar Reddy |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Scaffold medicine.medical_specialty Urologic Surgical Procedures Male Urethrotomy Urethral stricture Urology Urethroplasty medicine.medical_treatment Cell- and Tissue-Based Therapy 030232 urology & nephrology Pilot Projects Urethral stenosis 03 medical and health sciences 0302 clinical medicine Urethra stomatognathic system Recurrence medicine Humans Aged Urethral Stricture Tissue Scaffolds business.industry Mouth Mucosa Endoscopy Buccal administration Middle Aged Plastic Surgery Procedures medicine.disease Epithelium Surgery Treatment Outcome medicine.anatomical_structure 030220 oncology & carcinogenesis business Bulbar urethral stricture |
| Zdroj: | International Journal of Urology. 26:253-257 |
| ISSN: | 1442-2042 0919-8172 |
| Popis: | OBJECTIVES To describe the feasibility of a novel cell-based endoscopic technique using buccal epithelium, expanded and encapsulated in a thermoreversible gelation polymer scaffold for the treatment of urethral stricture. METHODS Six male patients with bulbar urethral stricture ranging from 2.0 to 3.5 cm in length were included in this pilot study. Autologous buccal epithelial cells from a small buccal mucosal biopsy were isolated, cultured and encapsulated in thermoreversible gelation polymer scaffold, and were implanted at the stricture site after a wide endoscopic urethrotomy. RESULTS All the patients voided well, with a mean peak flow rate of 24 mL/s. Urethroscopy carried out at 6 months showed healthy mucosa at the urethrotomy site. However, two of the six patients had recurrence at 18 and 24 months, respectively. CONCLUSIONS This endoscopic-based Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) technique is a promising alternative for the open substitution buccal graft urethroplasty. It is possible to achieve the benefits of open substitution buccal urethroplasty with this endoscopic technique. |
| Databáze: | OpenAIRE |
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