Impact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study
| Autor: | Yong Sung Kim, J S Kim, Jung Min Kim, Yeong-Jae Seok, Hyun Chae Jung, Joo Sung Kim, Cheol Min Shin, Yeon-Ran Kim, Ryoung Hee Nam, Ji Hyun Park, Dong Ho Lee, Nayoung Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Firmicutes 030106 microbiology Population Lansoprazole Pilot Projects Ileum Gut flora digestive system Gastroenterology Time 03 medical and health sciences 0302 clinical medicine RNA Ribosomal 16S Internal medicine Lactobacillus Escherichia medicine Humans Animals education Clostridium education.field_of_study Hepatology biology Small bowel intestinal overgrowth Proton Pump Inhibitors Sequence Analysis DNA biology.organism_classification Rats Inbred F344 Gastrointestinal Microbiome Rats Editorial medicine.anatomical_structure Endocrinology Original Article 030211 gastroenterology & hepatology Proteobacteria medicine.drug |
| Zdroj: | Gut and Liver |
| ISSN: | 2005-1212 1976-2283 |
| DOI: | 10.5009/gnl15529 |
| Popis: | Background/Aims: To evaluate changes in gut microbiota composition following long-term proton pump inhibitor (PPI) treatment. Methods: Twenty-four-week-old F344 rats were fed diets with (n=6) or without (n=5) lansoprazole for 50 weeks. Profiles of luminal microbiota in the terminal ileum were then analyzed. Pyrosequencing of the 16S rRNA gene was performed using an FLX genome sequencer (454 Life Sciences/Roche). Results: Rats treated with lansoprazole showed significantly reduced body weights compared to controls (lansoprazole-treated rats and controls, 322.3±15.3 g vs 403.2±5.2 g, respectively, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|