Advances in the diagnosis and management of human viral hepatitis

Autor: Michael Alan Siegel, Christine Wisnom
Rok vydání: 2003
Předmět:
Zdroj: Dental clinics of North America. 47(3)
ISSN: 0011-8532
Popis: Virologists theorize that the human hepatitis viruses have existed for longer than 2500 years [1]; however, technology was not sophisticated enough to identify the first human hepatitis virus in a cell culture until 1979 [1]. Since that time, the science of hepatology has identified several types of viral hepatitis including hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), hepatitis E virus (HEV), hepatitis F virus (HFV), hepatitis G virus (HGV), and the newly discovered transfusion-transmitted virus (TTV) [2]. Undoubtedly, in the future, virologists will identify many more hepatitis viruses yet undiscovered. Hepatitis is defined as an inflammation of the liver in which diffuse or patchy necrosis causes damage to the liver acini, resulting in destruction of the organ’s architecture [3]. A multitude of etiologic agents are responsible for hepatitis. Most hepatitis is of viral origin; Box 1 [4] illustrates the major causes of this disease, with a few examples listed in each category. The signs, symptoms, and stages of viral hepatitis vary greatly. Patients infected with hepatitis types A through G and TTV may be totally asymptomatic. When symptoms are experienced, they are often described as flulike. The signs and symptoms may include one or any combination of the following: fever, nausea, vomiting, diarrhea, joint and muscle pain, anorexia, jaundice, hepatomegaly, abdominal and gastric distention, dark urine, fatigue, bruising, rash, and chills [2,3].
Databáze: OpenAIRE