Fertility preservation in testicular cancer:predictors of spermatogenesis

Autor: Tet Yap, Jemma A. Moody, Majid Shabbir, Malene Roland Vils Pedersen, Catherine Horsfield, Kamran Ahmed
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Oncology
Male
#TCSM
Testis/physiology
0302 clinical medicine
Calcinosis/pathology
Testis
Orchiectomy/methods
Fertility preservation
Stage (cooking)
Young adult
030219 obstetrics & reproductive medicine
Age Factors
Calcinosis
Fertility Preservation
Neoplasms
Germ Cell and Embryonal
Middle Aged
Tumor Burden
Treatment Outcome
Fertility Preservation/methods
030220 oncology & carcinogenesis
Spermatogenesis/physiology
Adult
medicine.medical_specialty
endocrine system
Adolescent
Urology
03 medical and health sciences
Young Adult
Testicular Neoplasms
Internal medicine
medicine
Biomarkers
Tumor
Humans
Onco-TESE
Spermatogenesis
Neoplasms
Germ Cell and Embryonal/pathology
Tumor Burden/physiology
Testicular cancer
Testicular Neoplasms/pathology
Retrospective Studies
Aged
Neoplasm Staging
Organ Sparing Treatments/methods
business.industry
#TesticularCancer
Retrospective cohort study
medicine.disease
Orchidectomy
Biomarkers
Tumor/metabolism
Sperm Retrieval
business
Orchiectomy
Organ Sparing Treatments
Testicular microlithiasis
Zdroj: Moody, J A, Ahmed, K, Horsfield, C, Pedersen, M R V, Yap, T & Shabbir, M 2018, ' Fertility preservation in testicular cancer : predictors of spermatogenesis ', BJU International, vol. 122, no. 2, pp. 236-242 . https://doi.org/10.1111/bju.14214
DOI: 10.1111/bju.14214
Popis: OBJECTIVES: To determine the frequency of spermatogenesis in patients with testicular cancer and to assess for any predictors of spermatogenesis.PATIENTS AND METHODS: We retrospectively reviewed 103 testicular germ cell tumours (TGCTs) in men who underwent radical orchidectomy conducted at Guy's Hospital, London, between 2011 and 2015. Primary outcome measures included: the presence and characteristics of spermatogenesis (widespread/focal/proximity to tumour). Secondary outcome measures included: the presence of testicular microlithiasis, tumour characteristics (size, stage, and type), and tumour markers. Secondary outcome measures as potential predictors of spermatogenesis were assessed using univariate and multivariate logistic regression analyses.RESULTS: Spermatogenesis was present in 70% (72/103) of the patients; it was widespread in 63% (45/72) and focal in 38% (27/72). Neither tumour type, stage, presence of microcalcification nor tumour markers predicted spermatogenesis. Men with a percentage testis tumour occupation (PTTO) of >50% of their testis were 82% (95% confidence interval 73.2-98.4) less likely to have spermatogenesis than a PTTO of CONCLUSIONS: Spermatogenesis is present in most testes affected by TGCTs; it is widespread in two-thirds of patients, and located away from the tumour in 94%. These findings can help predict and guide successful surgical sperm retrieval in testes with TGCTs. The finding of focal spermatogenesis in a third of patients would support a microsurgical approach to sperm retrieval at the time of orchidectomy to maximise success.
Databáze: OpenAIRE
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