Emerging Role of IL-10 in Hypertrophic Scars
| Autor: | M L Yang, Guozhong Lv, Bin-Hong Zhao, Si-Yu Liu, Shun Yu, Zi-Li Sun, Ming-Li Zou, Zheng-Dong Yuan, Yi Feng, Jun-Jie Wu, Ji-Ru Zhang, Feng-Lai Yuan, Yong Du |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.medical_treatment wound healing Inflammation Review 030207 dermatology & venereal diseases 03 medical and health sciences Hypertrophic scar 0302 clinical medicine Fibrosis Medicine lcsh:R5-920 business.industry fibrosis hypertrophic scar General Medicine medicine.disease Pathophysiology Interleukin 10 030104 developmental biology Cytokine inflammation Hypertrophic scars interleukin 10 medicine.symptom lcsh:Medicine (General) business Wound healing |
| Zdroj: | Frontiers in Medicine, Vol 7 (2020) Frontiers in Medicine |
| ISSN: | 2296-858X |
| Popis: | Hypertrophic scars (HS) arise from traumatic or surgical injuries and the subsequent abnormal wound healing, which is characterized by continuous and histologically localized inflammation. Therefore, inhibiting local inflammation is an effective method of treating HS. Recent insight into the role of interleukin-10 (IL-10), an important anti-inflammatory cytokine, in fibrosis has increased our understanding of the pathophysiology of HS and has suggested new therapeutic targets. This review summarizes the recent progress in elucidating the role of IL-10 in the formation of HS and its therapeutic potential based on current research. This knowledge will enhance our understanding of the role of IL-10 in scar formation and shed new light on the regulation and potential treatment of HS. |
| Databáze: | OpenAIRE |
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