| Přispěvatelé: |
Cuadros, Sara, Rosso, Cristian, Giorgia Barison,, Costa, Paolo, Kurbasic, Marina, Bonchio, Marcella, Prato, Maurizio, Filippini, Giacomo, Luca Dell’Amico, And |
| Popis: |
A mild light-driven protocol for the direct alkylation of phenols is reported. The process is driven by the photochemical activity of a halogen-bonded complex formed upon complexation of the in situ generated electron-rich phenolate anion with the α-iodosulfone. The reaction proceeds rapidly (10 min) under microfluidic conditions, delivering a wide variety of ortho-alkylated products (27 examples, up to 97% yield, >20:1 regioselectivity, on a gram scale), including densely functionalized bioactive phenol derivatives. |
