Healing of rabbit calvarial critical-sized defects using autogenous bone grafts and fibrin glue
| Autor: | George K.B. Sándor, Olli-Pekka Lappalainen, Soili Kallio-Pulkkinen, Leena P. Ylikontiola, Willy Serlo, Jarkko T. Korpi, Petri Lehenkari, Marianne Haapea, Riikka M Korpi |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Bone flap Time Factors Tomography Scanners X-Ray Computed medicine.medical_treatment Dentistry Bone healing Fibrin Tissue Adhesive Functional Laterality Imaging Three-Dimensional medicine Animals Autogenous bone Solid bone Fibrin glue Wound Healing Bone Transplantation business.industry Ossification Cranial bone defects Skull General Medicine Cranioplasty Surgery Pediatrics Perinatology and Child Health Neurology (clinical) Rabbits medicine.symptom Bone Diseases business |
| Zdroj: | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 31(4) |
| ISSN: | 1433-0350 |
| Popis: | Purpose This study aimed to evaluate ossification of cranial bone defects comparing the healing of a single piece of autogenous calvarial bone representing a bone flap as in cranioplasty compared to particulated bone slurry with and without fibrin glue to represent bone collected during cranioplasty. These defect-filling materials were then compared to empty control cranial defects. Methods Ten White New Zealand adult male rabbits had bilateral critical-sized calvarial defects which were left either unfilled as control defects or filled with a single full-thickness piece of autogenous bone, particulated bone, or particulated bone combined with fibrin glue. The defects were left to heal for 6 weeks postoperatively before termination. CT scans of the calvarial specimens were performed. Histomorphometric assessment of hematoxylin-eosin- and Masson trichromestained specimens was used to analyze the proportion of new bone and fibrous tissue in the calvarial defects. Results There was a statistically significant difference in both boneand soft tissuepresent in all the autogenous bone-grafted defect sites compared to the empty negative control defects. These findings were supported by CT scan findings. While fibrin glue combined with the particulated bone seemed to delay ossification, the healing was more complete compared to empty control non-grafted defects. Conclusions Autogenous bonegraftsinvariousformssuchas solid bone flaps or particulated bone treated with fibrin glue were associated with bone healing which was superior to the empty control defects. |
| Databáze: | OpenAIRE |
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