Non-invasive diagnosis of lung tuberculosis in children by single voxel 1H-magnetic resonance spectroscopy
Autor: | Yay Chantana, Ianina Scheer, Denis R. St. Laurent, Phang Nan, Ky Santy, Beat Steinmann, David Nadal, Beat Richner |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Pathology
medicine.medical_specialty Tuberculosis Lung medicine.diagnostic_test biology Pleural effusion business.industry Lung tuberculosis Magnetic resonance imaging medicine.disease biology.organism_classification Mycobacterium tuberculosis medicine.anatomical_structure Pediatrics Perinatology and Child Health medicine Sputum medicine.symptom business Abscess |
Popis: | Our previous study showed that 1H-magnetic resonance spectroscopy (1H-MRS) can detect lipid peaks characteristic for Mycobacterium tuberculosis infection in cerebral lesions of young children; therefore, we aimed to extend and validate the application of 1H-MRS for the diagnosis of active pulmonary tuberculosis lesions in three adolescent patients. Here, we document lipid peaks characteristic for M. tuberculosis infection by 1H-MRS from lung tissue surrounding lung cavities of two patients whose sputum samples were positive for acid-fast bacilli by microscopy and positive for M. tuberculosis by genetic testing, indicating active tuberculosis. A similar lipid peak was found also in the pleural effusion of a third patient with concurrent lung cavity compatible with active tuberculosis. However, in a patient with a pyogenic pulmonary abscess, 1H-MRS of the drained pus displayed different characteristic peaks but no lipid peak at all. Conclusion: Our findings further validate 1H-MRS as a rapid, non-invasive, and specific diagnostic tool for active tuberculosis in children with microbiologically documented infection outside the central nervous system, specifically in the lungs. |
Databáze: | OpenAIRE |
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