Pyridoxine and atherosclerosis: role of pyridoxine in the metabolism of lipids and glycosaminoglycans in rats fed normal and high fat, high cholesterol diets containing 16% casein
| Autor: | PL Vijayammal, PA Kurup |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Normal diet Arteriosclerosis Hydrolases Phosphoadenosine Phosphosulfate High cholesterol Cholesterol Dietary chemistry.chemical_compound Endocrinology Internal medicine Casein Genetics medicine Animals General Materials Science Molecular Biology Aorta Glycosaminoglycans Cholesterol Sulfates Caseins Pyridoxine Lipid metabolism General Medicine Metabolism medicine.disease Lipid Metabolism Dietary Fats Rats Reproductive Medicine chemistry Liver Diet Atherogenic Animal Science and Zoology Developmental Biology Biotechnology medicine.drug |
| Zdroj: | Australian journal of biological sciences. 31(1) |
| ISSN: | 0004-9417 |
| Popis: | The effect of administration of low and high doses of pyridoxine on the metabolism of lipids and glycosaminoglycans has been studied in rats fed normal and high fat, high cholesterol diets. Low doses of pyridoxine (0.005 mg/100 g body weight) caused increased concentrations, of cholesterol and triglycerides in the serum and aorta in animals fed normal and high fat, high cholesterol diets. Administration of high doses of pyridoxine (5.0 mg/100 g body weight) caused decrease in the concentration of these lipids in these tissues except in the case of the aorta in the animals fed a normal diet. Low doses of pyridoxine generally caused a decrease in the concentration of many glycosaminoglycan fractions in the aorta in rats fed normal and high fat, high cholesterol diets, whilst high doses caused an increase. The activity of glucosaminephosphate isomerase (glutamine-forming) and UDPglucose dehydrogenase, both key enzymes in the biosynthetic pathway of glycosaminoglycans, decreased in rats given low doses of pyridoxine and increased in rats given high doses. The activity of many enzymes concerned with degradation of glycosaminoglycans--hyaluronoglucosidase, beta-glucuronidase, beta-N-acetylglucosaminidase, aryl sulphatase, and cathepsin D--generally increased in rats fed low doses of the pyridoxine and decreased in those given high doses. The concentration of hepatic 3'-phosphoadenosine-5'-phosphosulphate, and the activity of the sulphate-activating system and of aryl sulphotransferase decreased when the dose of pyridoxine was low and increased when the dose was high. |
| Databáze: | OpenAIRE |
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