Physiological and Genetic Adaptations to Diving in Sea Nomads
| Autor: | Melissa Ilardo, Peter de Barros Damgaard, Andaine Seguin-Orlando, Rasmus Nielsen, Fernando Racimo, Inge C.L. van den Munckhof, Jade Cheng, Simon Rasmussen, Eske Willerslev, Martin Sikora, Aaron J. Stern, Mihai G. Netea, Leo A. B. Joosten, Thorfinn Sand Korneliussen, Suhartini Salingkat, Rob ter Horst, Ida Moltke |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Erythrocytes Adolescent Diving Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Biology Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Indigenous White People Southeast asia Breath Holding 03 medical and health sciences Young Adult All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Asian People Ethnicity Humans 14. Life underwater Selection Genetic Hypoxia Lung Mammalian diving reflex Alleles Aged Aged 80 and over Natural selection Phosphoric Diester Hydrolases Genetic variants Subsistence agriculture Genetic Variation Genomics Organ Size Middle Aged Increased spleen size Adaptation Physiological Oxygen 030104 developmental biology Phenotype Evolutionary biology Indonesia Female Adaptation 030217 neurology & neurosurgery Spleen |
| Zdroj: | Ilardo, M A, Moltke, I, Korneliussen, T S, Cheng, J, Stern, A J, Racimo, F, de Barros Damgaard, P, Sikora, M, Seguin-Orlando, A, Rasmussen, S, van den Munckhof, I C L, Ter Horst, R, Joosten, L A B, Netea, M G, Salingkat, S, Nielsen, R & Willerslev, E 2018, ' Physiological and Genetic Adaptations to Diving in Sea Nomads ', Cell, vol. 173, no. 3, e15, pp. 569-580 . https://doi.org/10.1016/j.cell.2018.03.054 Cell, 173, 569-580.e15 Cell, 173, 3, pp. 569-580.e15 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2018.03.054 |
| Popis: | Understanding the physiology and genetics of human hypoxia tolerance has important medical implications, but this phenomenon has thus far only been investigated in high-altitude human populations. Another system, yet to be explored, is humans who engage in breath-hold diving. The indigenous Bajau people ("Sea Nomads") of Southeast Asia live a subsistence lifestyle based on breath-hold diving and are renowned for their extraordinary breath-holding abilities. However, it is unknown whether this has a genetic basis. Using a comparative genomic study, we show that natural selection on genetic variants in the PDE10A gene have increased spleen size in the Bajau, providing them with a larger reservoir of oxygenated red blood cells. We also find evidence of strong selection specific to the Bajau on BDKRB2, a gene affecting the human diving reflex. Thus, the Bajau, and possibly other diving populations, provide a new opportunity to study human adaptation to hypoxia tolerance. VIDEO ABSTRACT. |
| Databáze: | OpenAIRE |
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