Genome‑wide DNA hypomethylation drives a more invasive pancreatic cancer phenotype and has predictive occult distant metastasis and prognosis potential

Autor: Yuhei Endo, Koichi Suzuki, Yasuaki Kimura, Sawako Tamaki, Hidetoshi Aizawa, Iku Abe, Fumiaki Watanabe, Takaharu Kato, Masaaki Saito, Kazushige Futsuhara, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
Rok vydání: 2022
Předmět:
Zdroj: International journal of oncology. 60(6)
ISSN: 1791-2423
Popis: Genome‑wide DNA hypomethylation is the most common molecular feature in human cancers associated with chromosomal instability (CIN), which is involved in the mechanisms that regulate pancreatic cancer (PC) metastasis. It was investigated whether genome‑wide DNA hypomethylation affects the phenotype in PC via CIN
Databáze: OpenAIRE