Sural nerve biopsies in Guillain-Barre syndrome: axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome

Autor:	Susan M. Hall, Penny Atkinson, Philip J. Coates, Richard A. C. Hughes, Sidney Leibowitz
Rok vydání:	1992
Předmět:	Adult Male Pathology medicine.medical_specialty Genes Viral Physiology medicine.drug_class T-Lymphocytes Polyradiculoneuropathy Cytomegalovirus Sural nerve Monoclonal antibody Polymerase Chain Reaction law.invention Cellular and Molecular Neuroscience Sural Nerve law Physiology (medical) medicine Humans Polymerase chain reaction Aged Nerve biopsy Guillain-Barre syndrome medicine.diagnostic_test business.industry Macrophages Middle Aged medicine.disease Axons Microscopy Electron nervous system Immunology Nerve Degeneration Immunohistochemistry Female Neurology (clinical) business Infiltration (medical) Immunostaining Demyelinating Diseases
Zdroj:	Musclenerve. 15(5)
ISSN:	0148-639X
Popis:	T-cell infiltration was detected by immunohistochemistry in only 2 of 10 sural nerve biopsies from patients with Guillain-Barre syndrome (GBS). The number of endoneurial macrophages, identified by the monoclonal antibody MAC 387, was increased, compared with the number in 10 cases of axonal neuropathy. Macrophage-associated demyelination was identified in 7 and axonal degeneration in 8 cases. Cytomegalovirus (CMV) genome was not detected with the polymerase chain reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8abfcfb1b3abb26ede1c5b643c1a879 https://pubmed.ncbi.nlm.nih.gov/8423823 Zobrazit plný text záznamu Plný text