Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma
| Autor: | Manfred P. Wirth, Oliver W. Hakenberg, Johannes B.W. Nippgen, Michael Froehner, Stefan Zastrow |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Urology medicine.medical_treatment Metastatic Penile Carcinoma Bleomycin Antimetabolite chemistry.chemical_compound Penile Carcinoma Antineoplastic Combined Chemotherapy Protocols medicine Adjuvant therapy Carcinoma Humans Neoplasm Metastasis Penile Neoplasms Aged Retrospective Studies Chemotherapy business.industry Middle Aged medicine.disease Surgery Methotrexate Treatment Outcome chemistry Carcinoma Squamous Cell Disease Progression Cisplatin business medicine.drug |
| Zdroj: | BJU international. 98(6) |
| ISSN: | 1464-4096 |
| Popis: | OBJECTIVE To retrospectively evaluate the efficacy and toxicity of chemotherapy with cisplatinum, methotrexate and bleomycin (CMB) in the adjuvant and palliative setting, and its effect on survival in patients with locally advanced or metastatic penile carcinoma, which carries a very poor prognosis. PATIENTS AND METHODS Thirteen patients (mean age 54 years) with radically resected local and nodal disease (eight), metastatic disease (two) or metastatic recurrence (three) had chemotherapy with CMB between February 1996 and July 2003. In all, 45 treatment courses were given, with a mean (range) of 3.5 (2-6) courses per patient. RESULTS Three of the eight patients with adjuvant treatment showed no evidence of disease after a mean (range) of 54 (41-76) months, while four in this group died from disease progression after a mean of 11 (5-20) months, and one died from treatment-related toxicity. All five patients with metastatic disease died from disease progression after three had shown temporary signs of regression. CONCLUSIONS Chemotherapy with CMB had little effect on metastatic penile cancer and responses were transient. However, patients with minimal disease after radical local and lymphatic resection seemed to benefit from adjuvant therapy, but the toxicity was high and carried a risk of death. |
| Databáze: | OpenAIRE |
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