Two new phenylbutenoids from the rhizomes of cassumunar ginger and their α-glucosidase inhibitory activity

Autor: Tho Huu Le, Ngan Kim Thi Nguyen, Mai Thanh Thi Nguyen, Nhan Trung Nguyen
Rok vydání: 2022
Předmět:
Zdroj: Natural Product Research. :1-8
ISSN: 1478-6427
1478-6419
DOI: 10.1080/14786419.2022.2157826
Popis: An extract from the rhizomes of Cassumunar ginger (Zingiber purpureum Roscoe). was found to have significant α-glucosidase inhibitory activity with an IC50 value of 6.3 µg/mL. Two new phenylbutenoids, cassudimin A (1) and cassumunol N (2), and seven known compounds (3–9) were isolated. Their structures and relative configurations of two new compounds were elucidated based on spectra interpretation. Compounds 1–3, 6–9 showed more potent α-glucosidase inhibitory activity than a positive control, acarbose (IC50 = 168.0 µM). Dehydrozingerone (6) exhibited the most potent α-glucosidase inhibition with an IC50 value of 8.3 μM. Compounds 7 and 9 were found in Z. purpureum rhizomes for the first time.
Databáze: OpenAIRE
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