A primary tumour of the oesophagus with both melanocytic and schwannian differentiation. Melanocytic schwannoma or malignant melanoma?
| Autor: | L Papadaki, J Newman, G N Antonakopoulos, R M Brown, S J Darnton |
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| Rok vydání: | 2002 |
| Předmět: |
Pathology
medicine.medical_specialty Esophageal Neoplasms Case Report Pathology and Forensic Medicine Diagnosis Differential Fatal Outcome Biopsy medicine Humans Esophagus Melanoma Aged medicine.diagnostic_test business.industry Neurooncology Neural crest General Medicine medicine.disease Dysphagia medicine.anatomical_structure Immunohistochemistry Female medicine.symptom Differential diagnosis business Neurilemmoma |
| Zdroj: | Journal of Clinical Pathology. 55:318-320 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.55.4.318 |
| Popis: | A 76 year old white woman presented with a four month history of dysphagia and weight loss. Clinical, radiological, and endoscopic examination revealed a pigmented mass in the lower third of the oesophagus. The preoperative diagnosis, including biopsy examination, was that of malignant melanoma. Following oesophageal resection, the mass was found to be a localised, relatively superficial tumour with light, electron microscopic, and immunohistochemical features common to both Schwann cells and melanocytes. The patient survived 46 months after surgery and died of a stroke, with no evidence of tumour recurrence. The tumour is presented as a case of melanocytic schwannoma, with unique features when compared with oesophageal melanotic schwannomas and malignant melanomas described in the literature. The differential diagnosis is discussed and an origin from a common precursor cell of neural crest origin is postulated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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