Relaxation of the guinea-pig tracheal chain preparation by N6, 2‘-O-dibutyryl 3’,5‘-cyclic adenosine monophosphate
| Autor: | J M McManus, L C Iorio, P F Moore |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
Adenosine monophosphate medicine.medical_specialty Guinea Pigs Pharmaceutical Science Propranolol In Vitro Techniques Guinea pig chemistry.chemical_compound Hydrolysis Theophylline Internal medicine Isoprenaline Cyclic AMP medicine Animals Cyclic adenosine monophosphate Pharmacology Binding Sites Adenine Nucleotides Isoproterenol Phosphodiesterase Phosphoric Monoester Hydrolases Trachea Butyrates Endocrinology chemistry Cattle medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 20:368-372 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1968.tb09761.x |
| Popis: | N 6,2′-O-Dibutyryl 3′,5′-cyclic adenosine monophosphate (dibutyryl 3′,5′-amp), isoprenaline and theophylline relax the guinea-pig tracheal chain preparation; whereas 3′,5′-cyclic adenosine monophosphate (3′,5′-amp) does not. The relaxant effect of isoprenaline, but not that of dibutyryl 3′,5′-amp, was blocked by propranolol. 3′,5′-amp is hydrolyzed rapidly by beef heart phosphodiesterase whereas dibutyryl 3′,5′-amp is not. The presence of equimolar concentrations of dibutyryl 3′,5′-amp does not alter the rate of phosphodiesterase mediated hydrolysis of 3′,5′-amp. These data are consistent with the theories that relaxation of the guinea-pig trachea may be mediated by 3′,5′-amp and that dibutyryl 3′,5′-amp acts by mimicking 3′,5′-amp at its site of action. |
| Databáze: | OpenAIRE |
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