Extract of Juniperus indica Bertol Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade

Autor: Hung-Hsiu Liao, Ming-Chang Hsieh, Shan-Chih Lee, Xiao-Fan Huang, Kai-Fu Chang, Chia-Yu Li, Nu-Man Tsai
Rok vydání: 2020
Předmět:
Juniperus indica Bertol
medicine.medical_treatment
cisplatin
Pharmaceutical Science
Apoptosis
Drug resistance
Pharmacology
Juniperus indica
Madin Darby Canine Kidney Cells
Analytical Chemistry
Mice
0302 clinical medicine
Drug Discovery
Caspase
0303 health sciences
biology
Drug Synergism
Neoplasm Proteins
Chemistry (miscellaneous)
Caspases
030220 oncology & carcinogenesis
Molecular Medicine
Mouth Neoplasms
Adjuvant
medicine.drug
Article
lcsh:QD241-441
03 medical and health sciences
Dogs
lcsh:Organic chemistry
synergism
Cell Line
Tumor
medicine
Animals
Humans
Physical and Theoretical Chemistry
030304 developmental biology
Cisplatin
cell apoptosis
Plant Extracts
business.industry
Organic Chemistry
Cancer
oral cancer
biology.organism_classification
medicine.disease
Antineoplastic Agents
Phytogenic
Enzyme Activation
stomatognathic diseases
Juniperus
Cancer cell
biology.protein
business
Zdroj: Molecules
Molecules, Vol 25, Iss 2746, p 2746 (2020)
Volume 25
Issue 12
ISSN: 1420-3049
DOI: 10.3390/molecules25122746
Popis: Oral cancer&mdash
a type of head and neck cancer&mdash
is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. Juniperus indica Bertol is a plant of the Juniperus genus often used as a treatment in traditional medicine due to its anti-inflammatory, antibacterial and diuretic functions. The biofunctions of Juniperus indica Bertol including its anticancer potential, have not been fully explored. As a result, the aim of this research was to investigate the anticancer activity of Juniperus indica Bertol extract (JIB extract) and determine whether JIB extract has synergistic effects with cisplatin in oral cancer. These results are the first to demonstrate that JIB extract exhibits anticancer capacity and synergizes with cisplatin to treat oral cancer. Our findings indicate that JIB extract has a potential to develop anticancer agent and chemo therapeutic adjuvant for oral cancer.
Databáze: OpenAIRE
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