Mutations and functional analysis of 14-3-3 stress response protein from Triticum aestivum: An evolutionary analysis through in silico structural biochemistry approach
| Autor: | Chittabrata Mal, Arundhati Banerjee, Pragati Prasad Sah, Shreya Bhattacharya, Sujay Ray |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
In silico Biology Biochemistry Crop 03 medical and health sciences Protein Domains Stress Physiological Structural Biology Amino Acid Sequence Protein secondary structure Phylogeny Triticum Plant Proteins chemistry.chemical_classification Abiotic component Genetics Multiple sequence alignment Phylogenetic tree Organic Chemistry food and beverages Amino acid Salinity Computational Mathematics 030104 developmental biology 14-3-3 Proteins chemistry Mutation Thermodynamics Sequence Alignment |
| Zdroj: | Computational Biology and Chemistry. 77:343-353 |
| ISSN: | 1476-9271 |
| DOI: | 10.1016/j.compbiolchem.2018.09.013 |
| Popis: | Wheat (Triticum aestivum), having high nutritional values is one of the staple food of most of the countries in the world. The productivity of the crop decreases drastically when it encounters various abiotic stresses, most common of which are heat, drought, flood and salinity. There is a crucial role of stress response proteins for the survival of the crops in stress conditions. So the study of wheat stress response proteins is of great importance to raise wheat production in different stress conditions. In this study, we analysed 14-3-3 protein, a stress response protein that is expressed in three major stresses, for example heat, drought and salinity and helps the plants to survive in those conditions. Effect of mutations in the 14-3-3 sequence was predicted using its domain, secondary structure and multiple sequence alignment of amino acid sequences from wheat and its related species. The functional diversity of the protein in different species was correlated with mutations, change in secondary structure and the evolutionary relatedness of the protein in different species. This is the first novel work for analysing the mutational effect on the structure and function of a stress response protein (14-3-3) from Triticum aestivum and its related species. |
| Databáze: | OpenAIRE |
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