Estimating population size in wastewater-based epidemiology. Valencia metropolitan area as a case study
| Autor: | María Rico, Yolanda Picó, María Jesús Andrés-Costa |
|---|---|
| Přispěvatelé: | Ministerio de Economía y Competitividad (España), European Commission, Universidad de Valencia, Picó, Yolanda [0000-0002-9545-0965], Andrés-Costa, María Jesús [0000-0002-3509-9739], Picó, Yolanda, Andrés-Costa, María Jesús |
| Rok vydání: | 2016 |
| Předmět: |
Environmental Engineering
010504 meteorology & atmospheric sciences Substance-Related Disorders Health Toxicology and Mutagenesis Population Wastewater-based epidemiology Sewage 010501 environmental sciences Wastewater 01 natural sciences Population density Water Purification chemistry.chemical_compound Hydrochlorothiazide LC–MS/MS Environmental health Environmental Chemistry Medicine Cities education Waste Management and Disposal 0105 earth and related environmental sciences Population Density education.field_of_study Creatinine business.industry Illicit Drugs Population size Codeine Population estimation Pollution chemistry Spain Urine biomarkers Environmental chemistry business Cotinine Water Pollutants Chemical medicine.drug Environmental Monitoring |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1873-3336 |
| Popis: | Wastewater can provide a wealth of epidemiologic data on common drugs consumed and on health and nutritional problems based on the biomarkers excreted into community sewage systems. One of the biggest uncertainties of these studies is the estimation of the number of inhabitants served by the treatment plants. Twelve human urine biomarkers —5-hydroxyindoleacetic acid (5-HIAA), acesulfame, atenolol, caffeine, carbamazepine, codeine, cotinine, creatinine, hydrochlorothiazide (HCTZ), naproxen, salicylic acid (SA) and hydroxycotinine (OHCOT)— were determined by liquid chromatography-tandem mass spectrometry (LC–MS/MS) to estimate population size. The results reveal that populations calculated from cotinine, 5-HIAA and caffeine are commonly in agreement with those calculated by the hydrochemical parameters. Creatinine is too unstable to be applicable. HCTZ, naproxen, codeine, OHCOT and carbamazepine, under or overestimate the population compared to the hydrochemical population estimates but showed constant results through the weekdays. The consumption of cannabis, cocaine, heroin and bufotenine in Valencia was estimated for a week using different population calculations. This work has been supported by the Spanish Ministry of Economy and Competitiveness and the ERDF (European Regional Development Fund) through the project CGL2015-64454-C2-1-R and the University of Valencia through the project UV-INV-AE15-348995. M. Jesús Andrés-Costa also thanks the Spanish Ministry of Economy and Competitiveness for her FPI grant. |
| Databáze: | OpenAIRE |
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