Straightforward synthesis of chiral non-racemic α-boryl isocyanides
| Autor: | Mattia Stucchi, Alessandro Zanni, Maria Luisa Introvigne, Francesco Fini, Emilia Caselli, Fabio Prati |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Formamide
010405 organic chemistry Chemistry Bioactive molecules Organic Chemistry chemistry.chemical_element Sequence (biology) 010402 general chemistry 01 natural sciences Biochemistry Borylation Combinatorial chemistry 0104 chemical sciences Formylation chemistry.chemical_compound Dehydration reaction Physical and Theoretical Chemistry Boron |
| Zdroj: | Organicbiomolecular chemistry. 19(30) |
| ISSN: | 1477-0539 |
| Popis: | A straightforward concise synthesis of chiral non-racemic aliphatic α-boryl isocyanides, relay intermediates for boron-based bioactive molecules in multicomponent reactions, is presented. The short synthetic sequence comprises as key steps copper-catalysed asymmetric borylation of imines, simultaneous nitrogen formylation/boron-protecting group interconversion and the final formamide dehydration reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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