Smoking cessation intervention for patients with head and neck cancer: A prospective randomized controlled trial
| Autor: | F. Azoury, Georges Farha, Amine Haddad, Diane Helou, Nayla Matar, Clement Khoury, Hussein Smaily, Antoine E. Melkane, M.G. Khalaf, Tony Richa |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors media_common.quotation_subject Nicotine patch medicine.medical_treatment law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Prospective Studies 030223 otorhinolaryngology media_common Aged business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Alcohol dependence Perioperative Abstinence Middle Aged medicine.disease Head and neck squamous-cell carcinoma Tobacco Use Cessation Devices Treatment Outcome Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Smoking cessation Female Smoking Cessation business Follow-Up Studies |
| Zdroj: | American journal of otolaryngology. 42(1) |
| ISSN: | 1532-818X |
| Popis: | Aims To evaluate the effectiveness of a brief smoking cessation intervention in head and neck cancer patients (HNCP). Study design A prospective randomized controlled trial that randomly assigns participants in two groups: a usual care group (UCG), and a standardized intervention group (SIG). Material and methods Patients with a confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC) and who are active smokers were prospectively approached by one of 4 trained Ear-nose-throat (ENT) residents. Participants were randomized into a UCG, and a SIG consisting of a brief perioperative smoking cessation intervention based on National Institute of Health (NIH) “5A's” model along with an informative motivational document and nicotine patch therapy (NPT) offered for 8 weeks in gradually decreasing doses. Objective The evaluation of abstinence at 3, 6 and 12 months after enrollment. Results 56 subjects were randomized into the UCG (N = 29, 52%), and the SIG (N = 27, 48%). The overall smoking cessation rates were not statistically different between the two groups; we observed at 3 months cessation rates of 57.1% vs. 57.7% (p = 0.96); at 6 months, 42.9% vs. 24% (p = 0.148); and at 12 months, 33.3% vs. 20.8% (p = 0.318), for the UCG and the SIG respectively. Conclusion This study failed to show the effectiveness of a combined brief smoking cessation approach led by and ENT resident in HNSCC patients. A multifaceted approach addressing different pharmacological treatments, factors contributing to smoking maintenance, mainly alcohol dependence and mood disturbances and dealing with relapse risks through close face-to-face or phone call follow-ups may have better outcomes and should be evaluated in upcoming trials. |
| Databáze: | OpenAIRE |
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