Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes

Autor: Stuart Gormley, Stéphane Paulus, Sanjay Patel, Federico Martinón-Torres, Myrsini Kaforou, Colin Fink, Jethro Herberg, Kelsey D. J. Jones, Victoria J. Wright, Michael Levin, Giovanni Montana, Edward R. Sumner
Přispěvatelé: National Institute for Health Research
Rok vydání: 2013
Předmět:
viruses
Transcriptome
eIF-2 Kinase
Influenza A Virus
H1N1 Subtype
0302 clinical medicine
INFECTION
Gene expression
Cluster Analysis
Immunology and Allergy
Child
Regulation of gene expression
0303 health sciences
RSV
virus diseases
Bacterial Infections
11 Medical And Health Sciences
3. Good health
Infectious Diseases
Peptide Chain Initiation
030220 oncology & carcinogenesis
VIRUS
influenza
Life Sciences & Biomedicine
Signal Transduction
MICROBIOLOGY
Adolescent
respiratory tract infection
Immunology
Respiratory Syncytial Virus Infections
Biology
Virus
Major Articles and Brief Reports
03 medical and health sciences
Immune system
Influenza
Human
gene expression profiling
Humans
Gene
030304 developmental biology
Science & Technology
Microarray analysis techniques
Reproducibility of Results
06 Biological Sciences
respiratory tract diseases
Gene expression profiling
pediatric
Gene Expression Regulation
Protein Biosynthesis
Respiratory Syncytial Virus
Human
PATTERNS
microarray analysis
Zdroj: The Journal of Infectious Diseases. 208:1664-1668
ISSN: 1537-6613
0022-1899
Popis: We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.
Databáze: OpenAIRE
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