Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls
| Autor: | Yaraset López-Lorenzo, Jesús Arrieta, María Elena Sánchez-Mendoza, Audifás-Salvador Matus-Meza |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Drug media_common.quotation_subject Carbenoxolone Dehydrogenase Pharmacology Nitric Oxide Nitric oxide Lactones 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery medicine Animals Stomach Ulcer Sulfhydryl Compounds Rats Wistar media_common Ethanol Chemistry Anti-ulcer Agent Anti-Ulcer Agents 030104 developmental biology Mechanism of action 030220 oncology & carcinogenesis Prostaglandins medicine.symptom medicine.drug |
| Zdroj: | Drug Development Research. 79:11-15 |
| ISSN: | 0272-4391 |
| DOI: | 10.1002/ddr.21415 |
| Popis: | Hit, Lead & Candidate Discovery The gastroprotective effect of calealactone B, isolated from Calea urticifolia was assessed in an ethanol-induced model of gastric lesioning. The possible involvement of prostaglandins, nitric oxide (NO) and sulfhydryl groups in the mechanism of action of calealactone B was also assessed. Calealactone B inhibited ethanol-induced gastric injuries with a maximal effect (95.3 ± 2.6%) at 30 mg kg-1 . A similar value was obtained at 10 mg kg-1 (83.5 ± 7.7%). Meanwhile, the reference anti-ulcer drug, carbenoxolone, an 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitor administered at 30 mg kg-1 showed 63.5 ± 9.4% gastroprotection. Hence, calealactone B was more potent than carbenoxolone. Pretreatment with indomethacin, L-NAME or NEM did not reverse the effects of calealactone B, indicating that prostaglandins, NO and sulfhydryl compounds do not participate in its mechanism of action. |
| Databáze: | OpenAIRE |
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