Comparison of cardiac output measured by use of computed tomography and thermodilution in dogs
| Autor: | Clifford R. Berry, Sharon Tenenbaum, Fernando L Garcia-Pereira, Tori Obert |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Cardiac output 040301 veterinary sciences Butorphanol Thermodilution 030204 cardiovascular system & hematology Coronary Angiography 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine Etomidate Dobutamine medicine Animals Anesthesia Prospective Studies Cardiac Output Cross-Over Studies Isoflurane General Veterinary business.industry 04 agricultural and veterinary sciences General Medicine Crossover study Confidence interval Midazolam Female Tomography X-Ray Computed business medicine.drug |
| Zdroj: | American Journal of Veterinary Research. 78:906-909 |
| ISSN: | 0002-9645 |
| DOI: | 10.2460/ajvr.78.8.906 |
| Popis: | OBJECTIVE To compare cardiac output (CO) measured by use of CT coronary angiography and thermodilution (criterion-referenced standard) at various CO values, record adverse effects, and determine the time needed to measure CO. ANIMALS 5 healthy purpose-bred Beagles (2 males and 3 females). PROCEDURES A prospective nonrandomized crossover study was conducted. Dogs were premedicated with butorphanol tartrate (0.2 mg•kg−1, IM). Anesthesia was induced by IV administration of etomidate (1 to 2 mg•kg−1) and midazolam (0.25 mg•kg−1). Orotracheal intubation was performed, and anesthesia was maintained by administration of isoflurane. The CO was determined by use of thermodilution and by use of CT at 3 CO values. Dobutamine was infused at various rates to obtain the 3 CO values. RESULTS 13 values were obtained and analyzed. The mean ± SD difference between methods was 0.09 ± 0.71 L•min−1 (95% confidence interval [CI], 0.52 to −0.34 L•min−1). Only 1 of 13 values was located on the 100% agreement line (ie, 0 line), 7 of 13 values were located within the 95% CI, and 5 of 13 values were outside the 95% CI. CONCLUSIONS AND CLINICAL RELEVANCE For this study, there was poor agreement between the 2 methods. The 95% CI interval was 0.52 to −0.34 L•min−1, and 5 of 13 values were outside the 95% CI. Therefore, results for the CT method appeared to be inappropriate for use in making clinical decisions. |
| Databáze: | OpenAIRE |
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