Bromocriptine in the Treatment of Hyperolactinemic Amenorrhea
| Autor: | Alejandro Oliva, Diego Turner, Pedro R. Figueroa Casas, Omar A. Arcángeli, A.R Badano, Mirkin A, Héctor Miechi, Aníbal Rodríguez, Néstor J. Aparicio |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
medicine.medical_specialty Galactorrhea Adolescent media_common.quotation_subject Physiology Secondary amenorrhea Clomiphene Menstruation Serum prolactin Pregnancy medicine Humans In patient Amenorrhea Ovulation Bromocriptine media_common Gynecology business.industry Obstetrics and Gynecology Prolactin Reproductive Medicine Female medicine.symptom business Infertility Female medicine.drug |
| Zdroj: | Fertility and Sterility. 31:124-129 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)43810-0 |
| Popis: | Thirty women with secondary amenorrhea and hyperprolactinemia were studied; galactorrhea was present in 25 of them, and 18 were infertile. Serum prolactin (PRL) levels were high in all cases, between 26 and 120 ng/ml. All women were treated with bromocriptine in increasing doses from 2.5 to 5.0 or 7.5 mg daily, according to the response obtained, for 4 months. In 27 patients a PRL determination was performed during treatment; values returned to normal (up to 20 ng/ml) in 23 women and remained high in 4. Galactorrhea disappeared in 21 of 25 women. Ovulatory menses were re-established in 17 patients (56.6%). Seven women became pregnant (38.8%), one of them after bromocriptine and clomiphene were given simultaneously in the same cycle. According to our results and a literature review the following conclusions may be drawn: (1) bromocriptine is a useful therapeutic tool for re-establishing menstruation and inducing ovulation in patients with the hyperprolactinemic-amenorrhea syndrome; (2) the association of bromocriptine and clomiphene could be the next step in the treatment of patients who fail to ovulate with bromocriptine alone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|