Ventral striatum and stuttering: Robust evidence from a case-control study applying DARTEL
| Autor: | Bernd Weber, Benjamin Bleek, Martin Reuter, Christian Montag, Thilo Müller, Sebastian Markett, Jennifer Faber |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
pathology [Neostriatum] physiopathology [Neostriatum] physiopathology [Ventral Striatum] physiopathology [Gray Matter] lcsh:RC346-429 0302 clinical medicine pathology [Gray Matter] pathology [Ventral Striatum] Basal ganglia Gray Matter Putamen 05 social sciences Middle Aged pathology [Stuttering] Magnetic Resonance Imaging diagnostic imaging [Ventral Striatum] medicine.anatomical_structure Neurology diagnostic imaging [Neostriatum] lcsh:R858-859.7 Female medicine.symptom methods [Neuroimaging] Psychology Adult Stuttering Cognitive Neuroscience Neuroimaging Nucleus accumbens lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology 03 medical and health sciences Young Adult medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging ddc:610 lcsh:Neurology. Diseases of the nervous system Aged Ventral striatum diagnostic imaging [Gray Matter] Case-control study Voxel-based morphometry nervous system diseases Neostriatum physiopathology [Stuttering] Case-Control Studies Ventral Striatum diagnostic imaging [Stuttering] Speech disorder Neurology (clinical) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 23, Iss, Pp-(2019) NeuroImage: Clinical 23, 101890 (2019). doi:10.1016/j.nicl.2019.101890 |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2019.101890 |
| Popis: | A prominent theory of developmental stuttering highlights (dys-)function of the basal ganglia (and in particular the ventral striatum) as a main neural mechanism behind this speech disorder. Although the theory is intriguing, studies on gray matter volume differences in the basal ganglia between people who stutter and control persons have reported heterogeneous findings, either showing more or less gray matter volume of the aforementioned brain structure across the brain's hemispheres. Moreover, some studies did not observe any differences at all.From today's perspective several of the earlier studies are rather underpowered and also used less powerful statistical approaches to investigate differences in brain structure between people who stutter and controls. Therefore, the present study contrasted a comparably larger sample of n = 36 people who stutter with n = 34 control persons and applied the state of the art DARTEL algorithm (Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra) to analyze the available brain data. In the present data set stuttering was associated with higher gray matter volume of the right caudate and putamen region of the basal ganglia in patients. Our observation strongly supports a recent finding reporting a larger nucleus accumbens in the right hemisphere in people who stutter when compared to control persons. The present findings are discussed in the context of both compensatory effects of the brain and putative therapeutic effects due to treatment of stuttering. Keywords: Idiopathic stuttering, Developmental stuttering, Basal ganglia, Putamen, Caudate, Voxel based morphometry, DARTEL, Speech disorder |
| Databáze: | OpenAIRE |
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