Increased vitamin B6 turnover is associated with greater mortality risk in the general US population: A prospective biomarker study
| Autor: | Paula Schorgg, Nena Karavasiloglou, Anika Beyer, Marie Cantwell, Ina Danquah, Jan Gojda, Sabine Rohrmann, Aedin Cassidy, Till Bärnighausen, Monika Cahova, Tilman Kühn |
|---|---|
| Přispěvatelé: | University of Zurich, Kühn, Tilman |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Aged 80 and over Nutrition and Dietetics 610 Medicine & health 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) Middle Aged Nutrition Surveys Critical Care and Intensive Care Medicine Vitamin B 6 Young Adult SDG 3 - Good Health and Well-being Neoplasms Pyridoxal Phosphate Humans 2916 Nutrition and Dietetics Prospective Studies 2706 Critical Care and Intensive Care Medicine Biomarkers Aged |
| Zdroj: | Schorgg, P, Karavasiloglou, N, Beyer, A, Cantwell, M, Danquah, I, Gojda, J, Rohrmann, S, Cassidy, A, Bärnighausen, T, Cahova, M & Kühn, T 2022, ' Increased vitamin B6 turnover is associated with greater mortality risk in the general US population: A prospective biomarker study ', Clinical Nutrition, vol. 41, no. 6, pp. 1343-1356 . https://doi.org/10.1016/j.clnu.2022.04.023 |
| DOI: | 10.5167/uzh-227981 |
| Popis: | BACKGROUND & AIMS: Vitamin B6 status and mortality risk are inversely associated in different patient groups, while prospective studies in the general population are lacking. Here, for the first time, we evaluated the association between biomarkers of vitamin B6 status and mortality risk in a large population-based study.METHODS: The vitamin B6 vitamers pyridoxal-5'-phosphat (PLP) and 4-pyridoxic acid (4-PA) were measured by high-performance liquid chromatography in the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2010. Participants' vital status and causes of death were recorded until December 2015. Multivariable Cox regression analyses were carried out to estimate Hazard Ratios (HRs) and 95% confidence intervals (CIs) of mortality across quintiles of PLP, 4-PA, and the ratio of 4-PA and PLP.RESULTS: Out of 15,304 study participants aged between 20 and 85 years at baseline, 1666 (7.7%) died during a median follow-up time of 7.8 years. An inverse association between PLP and mortality was found in a multivariable model adjusted for socioeconomic and lifestyle factors but became statistically non-significant upon adjustment for routine biomarkers (C-reactive protein, creatinine, albumin, and alkaline phosphatase). There was a significant linear trend for a positive association between 4-PA levels and mortality risk in the fully adjusted regression model, although a comparison of extreme quintiles (quintile 5 vs. quintile 1) did not show a significant difference (HRQ5vs.Q1 (95% CI): 1.19 (0.93, 1.51), plinear trend = 0.02). A positive association between the 4-PA/PLP ratio and all-cause mortality was observed in the multivariable model, with an HRsQ5vs.Q1 of 1.45 (95% CI: 1.14, 1.85; plinear trendCONCLUSION: Increased vitamin B6 turnover, as indicated by a higher 4-PA/PLP ratio, was associated with all-cause and cancer mortality among the older U.S. general population. Intervention trials are needed to assess whether older individuals with a high 4-PA/PLP ratio would benefit from increased vitamin B6 intake. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|