Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence
| Autor: | Derek LeRoith, Ruslan Novosyadlyy, D. Lann, Emily J. Gallagher, Archana Vijayakumar, Shoshana Yakar |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
medicine.medical_specialty Endocrinology Diabetes and Metabolism Type 2 diabetes Models Biological Proinflammatory cytokine Endocrinology Insulin resistance Risk Factors Internal medicine Diabetes mellitus Neoplasms Internal Medicine medicine Hyperinsulinemia Animals Humans Obesity Risk factor business.industry nutritional and metabolic diseases Cancer General Medicine medicine.disease Prognosis Disease Models Animal Diabetes Mellitus Type 2 business Signal Transduction |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 116 |
| ISSN: | 0947-7349 |
| Popis: | Both obesity and Type 2 diabetes are independently associated with an increased risk of developing cancer and an increased mortality. The etiology is yet to be determined but insulin resistance and hyperinsulinemia maybe important factors. Hyperglycemia, hyperlipidemia and inflammatory cytokines in addition to the insulin-like growth factors are also possible factors involved in the process. |
| Databáze: | OpenAIRE |
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