THE PROTECTIVE ROLE OF ESTRADIOL & PROGESTERONE IN MALE RATS, FOLLOWING GASTRIC ISCHEMIA-REPERFUSION
| Autor: | Z. Keshavarzi, N. Mohammadzadeh, Reza Mohebbati, V. Alikhani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Ischemia Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Male rats Medicine Estradiol / Progesterone General Endocrinology biology Endocrine and Autonomic Systems business.industry Therapeutic effect Glutathione medicine.disease chemistry 030220 oncology & carcinogenesis Myeloperoxidase biology.protein Gastric acid 030211 gastroenterology & hepatology business |
| Popis: | Background and Aim. Ischemia-reperfusion (I/R) injury frequently occurs in different situations. Female sex hormones have a protective function. The purpose of this study was to determine the function of female sexual hormones on the gastric damage induced by UR in male rats. Methods. Forty (40) Wistar rats were randomized into five groups: intact, ischemia- reperfusion (IR), IR + estradiol (1mg/kg), IR + progesterone (16 mg / kg) and IR + combination of estradiol (1mg / kg) and progesterone (16 mg/ kg). Before the onset of ischemia and before reperfusion all treatments were done by intraperitoneal (IP) injection. After animal anesthesia and laparotomy, celiac artery was occluded for 30 minutes and then circulation was established for 24 hours. Results expressed as mean +/- SEM and P |
| Databáze: | OpenAIRE |
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