Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study

Autor: Siyu Liu, Kathleen E. Rodgers, Ahmet Baydur, Stan G. Louie, Janice M. Liebler, Isaac Asante, Pranay Parikh, Raju Reddy, Zea Borok
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
ARDS
Critical Care and Emergency Medicine
Pulmonology
Physiology
Enzyme Metabolism
Pilot Projects
030204 cardiovascular system & hematology
Gastroenterology
Biochemistry
0302 clinical medicine
Tandem Mass Spectrometry
Blood plasma
Medicine and Health Sciences
Renal Failure
Enzyme Chemistry
Acute Respiratory Distress Syndrome
Chromatography
High Pressure Liquid
education.field_of_study
Respiratory Distress Syndrome
Multidisciplinary
Receptors
Angiotensin
biology
Middle Aged
Body Fluids
Enzymes
Blood
Nephrology
Angiotensin-converting enzyme 2
Acute Disease
Medicine
Female
Angiotensin-Converting Enzyme 2
Anatomy
Research Article
Agonist
Adult
medicine.medical_specialty
medicine.drug_class
Death Rates
Science
Peptidyl-Dipeptidase A
Blood Plasma
03 medical and health sciences
Respiratory Failure
Population Metrics
Internal medicine
Renin–angiotensin system
medicine
Humans
education
Population Biology
business.industry
Ras Peptide
Biology and Life Sciences
Proteins
Angiotensin-converting enzyme
Kidneys
Renal System
medicine.disease
Angiotensin II receptor type 2
030104 developmental biology
biology.protein
Enzymology
Angiotensin I
business
Peptides
Biomarkers
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0213096 (2019)
ISSN: 1932-6203
Popis: RationaleWe propose renin angiotensin system (RAS) peptides are critical in wound reparative processes such as in acute respiratory distress syndrome (ARDS). Their role in predicting clinical outcomes in ARDS has been unexplored; thus, we used a targeted metabolomics approach to investigate them as potential predictors of outcomes.MethodsThirty-nine ARDS patients were enrolled within 24 hours of ARDS diagnosis. Plasma RAS peptide levels were quantified at study entry and 24, 48 and 72 hours using a liquid chromatography-mass spectrometry based metabolomics assay. RAS peptide concentrations were compared between survivors and non-survivors, and were correlated with clinical and pulmonary measures.Measurements and main resultsAngiotensin I (Ang-I or A(1-10)) levels were significantly higher in non-survivors at study entry and 72 hours. ARDS survival was associated with lower A(1-10) concentration (OR 0.36, 95% CI 0.18-0.72, p = 0.004) but higher A(1-9) concentration (OR 2.24, 95% CI 1.15-4.39, p = 0.018), a biologically active metabolite of A(1-10) and an agonist of angiotensin II receptor type 2. Survivors had significantly higher median A(1-9)/A(1-10) and A(1-7)/A(1-10) ratios than the non-survivors (p = 0.001). Increased A(1-9)/A(1-10) ratio suggests that angiotensin converting enzyme II (ACE2) activity is higher in patients who survived their ARDS insult while an increase in A(1-7)/A(1-10) ratio suggests that ACE activity is also higher in survivors.ConclusionA(1-10) accumulation and reduced A(1-9) concentration in the non-survivor group suggest that ACE2 activities may be reduced in patients succumbing to ARDS. Plasma levels of both A(1-10) and A(1-9) and their ratio may serve as useful biomarkers for prognosis in ARDS patients.
Databáze: OpenAIRE
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