A Chorionic Gonadotropin-Secreting Human Pituitary Cell*
| Autor: | E. Hammond, Jeanine Griffin, William D. Odell |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Cell type Pituitary gland medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Immunocytochemistry Gonadotropin-releasing hormone Biology Monoclonal antibody Immunofluorescence Chorionic Gonadotropin Biochemistry Endocrinology Culture Techniques Internal medicine medicine Humans reproductive and urinary physiology medicine.diagnostic_test urogenital system Biochemistry (medical) Luteinizing Hormone Immunohistochemistry Microscopy Electron medicine.anatomical_structure Pituitary Gland Female Gonadotropin hormones hormone substitutes and hormone antagonists Endocrine gland |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 72:747-754 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-72-4-747 |
| Popis: | Recent data from our laboratory show that hCG is secreted in a pulsatile manner in parallel with human LH (hLH) in nonpregnant normal humans. Furthermore, GnRH stimulates hCG and hLH release. Using a monoclonal antibody specific for the β-chain of hCG and not reacting with hLH, we have identified a heretofore unknown cell type in human pituitaries which stains only for hCG. The light microscopic, immunocytochemical, and ultrastructural features are described. These data coupled to those from multiple earlier studies indicate that hCG is secreted by these cells in normal nonpregnant humans. (J Clin Endocrinol Metab 72: 747–754, 1991) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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