Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response
| Autor: | Chun-Yang Lin, Joshua Wolf, David C. Brice, Yilun Sun, Macauley Locke, Sean Cherry, Ashley H. Castellaw, Marie Wehenkel, Jeremy Chase Crawford, Veronika I. Zarnitsyna, Daniel Duque, Kim J. Allison, E. Kaitlynn Allen, Scott A. Brown, Alexandra H. Mandarano, Jeremie H. Estepp, Charles Taylor, Carmen Molina-Paris, Stacey Schultz-Cherry, Li Tang, Paul G. Thomas, Maureen A. McGargill, Aditya H. Gaur, James M. Hoffman, Tomi Mori, Elaine I. Tuomanen, Richard J. Webby, Hana Hakim, Randall T. Hayden, Diego R. Hijano, Walid Awad, Resha Bajracharya, Brandi L. Clark, Valerie Cortez, Ronald H. Dallas, Thomas Fabrizio, Pamela Freiden, Ashleigh Gowen, Jason Hodges, Allison M. Kirk, Ericka Kirkpatrick Roubidoux, Robert C. Mettelman, Jamie Russell-Bell, Aisha Souquette, James Sparks, Lee-Ann Van de Velde, Ana Vazquez-Pagan, Kendall Whitt, Taylor L. Wilson, David E. Wittman, Nicholas Wohlgemuth, Gang Wu |
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| Rok vydání: | 2022 |
| Předmět: |
viruses
Common Cold pre-existing immunity Cross Reactions Antibodies Viral Microbiology Article Cell Line Mice antibody Virology Animals Humans skin and connective tissue diseases 229E Asymptomatic Infections SARS-CoV-2 fungi virus diseases COVID-19 OC43 biochemical phenomena metabolism and nutrition Immunity Humoral Mice Inbred C57BL HEK293 Cells NL63 Case-Control Studies Antibody Formation Spike Glycoprotein Coronavirus Female Parasitology HKU1 |
| Zdroj: | Cell Host & Microbe |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2021.12.005 |
| Popis: | SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to respiratory distress and death. A major unresolved question is whether prior immunity to endemic, human common cold coronaviruses (hCCCoV) impacts susceptibility to SARS-CoV-2 infection or immunity following infection and vaccination. Therefore, we analyzed samples from the same individuals before and after SARS-CoV-2 infection or vaccination. We found hCCCoV antibody levels increase after SARS-CoV-2 exposure, demonstrating cross-reactivity. However, a case-control study indicates baseline hCCCoV antibody levels are not associated with protection against SARS-CoV-2 infection. Rather, higher magnitudes of pre-existing betacoronavirus antibodies correlate with more SARS-CoV-2 antibodies following infection, an indicator of greater disease severity. Additionally, immunization with hCCCoV spike proteins before SARS-CoV-2 immunization impedes generation of SARS-CoV-2 neutralizing antibodies in mice. Together, these data suggest pre-existing hCCCoV antibodies hinder SARS-CoV-2 antibody-based immunity following infection and provide insight on how pre-existing coronavirus immunity impacts SARS-CoV-2 infection, which is critical considering emerging variants. Graphical Abstract A major unresolved question is whether prior immunity to endemic, human common cold coronaviruses (hCCCoV) impacts susceptibility to SARS-CoV-2 infection. Lin et al. analyze hCCCoV antibodies in the same individuals before and after SARS-CoV-2 infection, finding pre-existing betacoronavirus antibodies may hinder SARS-CoV-2 effective immunity following infection. |
| Databáze: | OpenAIRE |
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